P4Health: Center of Excellence in Precise Phenotyping and BioDataBanking for Personalised Brain Health.
Project is carried out within the
MAB/IRA programme of the Foundation for Polish Science.
The P4Health Centre of Excellence is an interdisciplinary initiative focused on advancing Predictive, Preventive, Personalized, and Participatory (P4) approaches in health and medicine.
Within the
IRAP framework, the project’s scientific goal is to discover and validate novel therapeutic concepts aimed at counteracting symptoms of brain disorders associated with astrocyte pathology.
The applied research programme is designed to deliver a detailed understanding of the mechanisms of astrocyte dysfunction and its impact on neuronal networks, building on the complementary expertise of a team with a strong publication record in reputable journals and proven experience in identifying nervous system pathomechanisms and developing prototype drug candidates.
Project outcomes will be protected as intellectual property and will provide a foundation for translation through clinical studies and appropriate commercialisation pathways.
P4Health’s key features: • Interdisciplinary centre advancing P4 approaches in health and medicine • Applied, mechanism-driven research focused on astrocyte dysfunction and its effects on neuronal networks • Strong scientific track record demonstrated through high-quality publications and prior discoveries in nervous system pathomechanisms • Translation-oriented strategy, from concept validation to clinical studies and commercialisation • Systematic protection and management of intellectual property to support downstream implementation Position description: P4Health CoE is seeking an ambitious and motivated Postdoctoral Researcher to join studies investigating astrocytic protein quality control in Alzheimer’s disease.
Neurodegenerative diseases (NDDs) are devastating, age-related disorders that, despite substantial research efforts, remain largely incurable.
Our work employs cutting-edge approaches to advance understanding of the molecular mechanisms of neurodegeneration, with the ultimate aim of proposing novel therapeutic strategies.
In your role, you will use cell reprogramming methods and implement the state-of-the-art human model systems to investigate the origin and progression of the Alzheimer’s disease pathology.
The deposition of misfolding-prone proteins is a hallmark of NDDs and consistent evidence points to the dysregulation of protein quality control (PQC) in neurodegenerative pathogenesis.
We have previously demonstrated that boosting the PQC can be beneficial in preventing protein misfolding as well as ameliorating neurodegenerative phenotypes (Das, Krzyzosiak et al.
2015, Science;
Krzyzosiak, Sigurdardottir et al.
2018, Cell).
Building on these findings, our aim is to systematically investigate the molecular components of PQC pathways and to exploit their potential to modify NDD-associated cellular pathology.
The position is intended for a person holding a doctoral degree for no longer than 5 years.
The 5-year period is counted from the year of obtaining the doctoral degree.
This period begins with the annual data of obtaining the degree, and ends with the year preceding the completion date, which may occur through a competition.
The 5-year period may be extended to include any interrupted periods of research work occurring after obtaining the degree, provided that the interruption lasts no less than 6 months.
We encourage applications from candidates of all nationalities, genders and backgrounds.